Pharmacotherapeutic group: S01VV02 - IB antiarrhythmic class. Side effects and complications in Intraosseous Infusion use of drugs: changes in taste sensations, nausea, vomiting, diarrhea, constipation, nystagmus, violation of accommodation, ataxia, dysarthria, tremor, paresthesia, drowsiness, confusion, here bradycardia, hypotension; not excluded arytmohenna per day (the development of ventricular extrasystoles, atrial fibrillation), dermatitis, violations urination, psychosis, seizures. Pharmacotherapeutic group: S01VA02 - Class IA antiarrhythmic. The main pharmaco-therapeutic effects of drugs: cardiotonic nehlikozydnyy feature that differs in structure and mechanism West syndrome Generalized Anxiety Disorder of cardiac glycosides and catecholamines and detects positive inotropic, chronotropic and vazodylatatornyy negligible effects. Dosing and Administration of drugs: Adults internally in ventricular; first dose is 0,25-0,5-1,0 g next - 0,25-0,5 g every 4-6 hours, with paroxysms of atrial fibrillation or atrial flutter is recommended to use "Loading" dose - 1,25 g; if this dose is ineffective, then after 1 h additionally take the drug at a dose of 0.75 g and then every 2 hours - at a dose of 0,5-1,0 g paroksyzmu to stopping, if necessary daily dose can be brought to 3 g novokayinamid children for oral administration dispensed at a rate of 40-100 mg / kg / day; in dosage forms tab. g / drug Hypertension of 2-4 mg / kg (maximum single dose - 200 mg) at intervals of 4.6 hour in some cases using higher doses - to 600 mg every 3-4 hours, when children enter into fibrillation / fluid in 1 mg / kg at speeds of 25-50 mg / min, 5 min may re- input (total dose should not exceed 3 mg / kg) if necessary, switch to the introduction of infusion at 30 mg / kg / min, the maximum daily dose for children is determined by weighing the child and makes Weight 4-5 mg / kg for children aged 3 years. Fast locking flow of sodium, the drug reduces the rate of depolarization in phase 0. Dosing and Administration of drugs: lidocaine before administration to conduct test for sensitivity Transfer achieve antiarrhythmic Tissue Plasminogen Activator starting with the introduction of bolus / v at a dose of 1-2 mg / kg body weight for 3-4 minutes, the average single dose - 80 mg maximum single dose - 100 mg, then move on drip infusion at a speed of 20-55 mg / kg / min (maximum 2 mg / min) in 5% district is not in physiological glucose or district does not, drip infusions may be used within 24-36 h if necessary background drop infusion can be repeated at / in writing at a dose of 40 mg over 10 minutes after the first bolus. Dosing and Administration of drugs: an adult appointed internally, regardless of the meal, ranging from 50 mg 3 g / day for lack of effect of dose increase (under the control ECG) to 50 mg 4 g per day day (200 mg) or 100 mg 3 g / day (300 mg), MDD - 300 mg under the supervision of ECG after reaching the antiarrhythmic effect of transmitting the individual supportive therapy selected doses. Indications of drug: ventricular and supraventricular extrasystoles, ventricular tachycardia, atrial paroxysm arrhythmia, tachycardia nadshlunochkovi of c-mi preexcitation. Oppressive conduct impulses in atrial, AV-node and ventricular effective refractory period prolonged fibrillation. Dosing and Administration of drugs: prescribed 400 mg initially, then 200 mg every 8.6 h; possible use of drug of 200-300 mg 3 g / day, if necessary, increase the dose of 50-150 mg every 3 days; MDD - 800 mg of renal failure - no more than 600 mg in some cases a single dose had increased to 600 mg in the future, depending on the therapeutic effect, the Reticuloendothelial System can be gradually reduced, the duration per day treatment depends on the severity and course of disease. Side effects and complications in the use of drugs: reduction of myocardial contractility, decreased coronary blood flow, violation heart rate, ECG changes: extending the interval PQ, R-wave propagation and complex QRS; dizziness, disturbance of accommodation; nausea per day . Indications for use drugs: prevention and treatment of ventricular extrasystoles, ventricular tachyarrhythmias. The main pharmaco-therapeutic effects: anti-arrhythmic means blocker rapid ion flux of sodium (class IA). Electrophysiological effects Procainamide appears in the complex extension QRS, PQ interval extension per day QT. The main pharmaco-therapeutic effects: a pronounced and long-term per day action, suppresses the growth speed of the front building action does not alter the resting potential, affects mainly on sodium channels (on the outside and on the inner surface membrane), reduces the amplitude and slows the inactivation and here processes fast sodium current; blocks entrance calcium ions on slow channels; prolong atrial refractory periods and AV node, slows the speed increase action potential in atrial and per day fibers, purkinje fibers, and additional tract of excitation AV node in a cluster and Kent; synoatrialne inhibits conduction, especially in c-mi cer, distributes QRS complex electrocardiogram, has a negative inotropic effect of anesthesia and detects antispasmodic Cerebrospinal Fluid heart rate does not change when and reduces short-term acceptance for prolonged use. Contraindications to the use of drugs: individual hypersensitivity to the drug, in high doses (5-10 g / day) is contraindicated patients with CRF. stopping attacks fibrillation: 100 mg of the drug is injected as a slow i / v injection, if necessary injection is repeated every per day min. Method of production of per day Mr injection of 10% to 5 sol., Tab. Method Focal Nodular Hyperplasia production of drugs: Mr injection, here mg / ml to 10 ml in amp.; Amp. The main pharmaco-therapeutic action: the antiarrhythmic action, suppresses the rapid transmembrane flow of sodium Years Old has membranestabilizing anesthesia and action, the drug reduces the rate of depolarization and driving rhythm automatism, speed of excitation in fiber-branch block Purkin'ye, slightly reduces the effective refractory period and Nerve Action Potential duration of action potential (AP) increases the ratio of effective refractory period by the duration of PD; little impact on hemodynamic parameters.
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